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- Epidemiology
- Serum 25-Hydroxyvitamin D Concentration Is Independently Inversely Associated with Insulin Resistance in the Healthy, Non-Obese Korean Population
- So Young Ock, Kyoung Hwa Ha, Bu Kyung Kim, Hyeon Chang Kim, Jee-Seon Shim, Myung Ha Lee, Young Me Yoon, Dae Jung Kim
- Diabetes Metab J. 2016;40(5):367-375. Published online July 26, 2016
- DOI: https://doi.org/10.4093/dmj.2016.40.5.367
- 3,735 View
- 31 Download
- 9 Web of Science
- 9 Crossref
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Abstract
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Supplementary Material
PubReader Background We evaluated the associations between 25-hydroxyvitamin D (25(OH)D) concentrations in serum and insulin resistance in the healthy Korean population.
Methods We conducted this cross-sectional analysis in 1,807 healthy Korean people (628 men and 1,179 women) aged 30 to 64 years in the Cardiovascular and Metabolic Disease Etiologic Research Center study. All participants were assessed for 25(OH)D, fasting glucose, and insulin levels, and completed a health examination and lifestyle questionnaire according to standard procedures. Insulin resistance was defined as the homeostasis model assessment insulin resistance higher than the 75 percentile.
Results Compared to those in the highest tertile (≥14.3 ng/mL), the odds ratio (OR) for insulin resistance was 1.37 (95% confidence interval [CI], 1.01 to 1.86) for the 1st tertile (<9.7 ng/mL) and 1.19 (95% CI, 0.08 to 1.62) for the 2nd tertile (9.7 to 14.3 ng/mL) after adjusting for age, gender, waist circumference, alcohol consumption, smoking status, physical exercise, season, and cohort. After stratification of the subjects by adiposity, these associations remained only in non-obese subjects (lowest tertile vs. highest tertile, multivariable OR, 1.64; 95% CI, 1.05 to 2.56).
Conclusion Serum 25(OH)D has an independent inverse association with insulin resistance in the healthy, non-obese Korean population, even among people with vitamin D insufficiency.
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Citations
Citations to this article as recorded by
- Vitamin D and Cardiovascular Diseases: An Update
Farrookh Haider, Hashsaam Ghafoor, Omar F Hassan, Khalid Farooqui, Ali O. Mohamed Bel Khair, Faryal Shoaib
Cureus.2023;[Epub] CrossRef - Vitamin D as predictor Marker of kidney disease in males with type 2 diabetes mellitus
Abeer J. Hassan, Sarmad Ajeel Hazzaa, Dunya Najim Alden Ahmed
Bionatura.2022; 7(2): 1. CrossRef - Vitamin D Effect on Ultrasonography and Laboratory Indices and Biochemical Indicators in the Blood: an Interventional Study on 12 to 18-Year-Old Children with Fatty Liver
Kokab Namakin, Mahya Hosseini, Mahmoud Zardast, Mahyar Mohammadifard
Pediatric Gastroenterology, Hepatology & Nutrition.2021; 24(2): 187. CrossRef - The Association between Vitamin D and Nonalcoholic Fatty Liver Disease Assessed by Controlled Attenuation Parameter
Nam Ju Heo, Hyo Eun Park, Ji Won Yoon, Min-Sun Kwak, Jong In Yang, Su Jin Chung, Jeong Yoon Yim, Goh Eun Chung
Journal of Clinical Medicine.2021; 10(12): 2611. CrossRef - Association between serum 25-hydroxy vitamin D level and metabolic associated fatty liver disease (MAFLD)—a population-based study
Bo Wan, Yuan Gao, Yushan Zheng, Ruanqin Chen
Endocrine Journal.2021; 68(6): 631. CrossRef - Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience
Vincenzo Pilone, Salvatore Tramontano, Carmen Cutolo, Federica Marchese, Antonio Maria Pagano, Federica Di Spirito, Luigi Schiavo
International Journal for Vitamin and Nutrition Research.2020; 90(3-4): 346. CrossRef - Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Yoosik Youm, Eui-Cheol Shin, Hyeon Chang Kim
Yonsei Medical Journal.2019; 60(8): 804. CrossRef - Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort: study protocol and results of the first 3 years of enrollment
Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Hyeon Chang Kim
Epidemiology and Health.2017; 39: e2017016. CrossRef - Vitamin D and coronary atherosclerosis
Dae Jung Kim
Osteoporosis and Sarcopenia.2017; 3(4): 201. CrossRef
- Vitamin D and Cardiovascular Diseases: An Update
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